Article
Increased frequency of in vivo hprt gene-mutated T cells in the peripheral blood of patients with systemic sclerosis.
Annals of the rheumatic diseases - 1 Feb 1994
Sfikakis P P, Tesar J, Theocharis S, Klipple G L, Tsokos G C
Abstract excerpt
OBJECTIVE: Activated T lymphocytes are involved in the pathogenesis of scleroderma (systemic sclerosis, SSc); such cells rapidly divide in vivo and are thus theoretically subject to random mutation more frequently than resting cells. To study whether SSc is associated with rapidly expanding T cel...
Topics
- Adolescent
- Adult
- Aged
- Cells, Cultured
- Child
- Clone Cells
- Female
- Fluorescent Antibody Technique
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Immunophenotyping
- Lymphocyte Activation
- Male
- Middle Aged
- Mutation
- Phenotype
- Scleroderma, Systemic
- T-Lymphocytes