Article
A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain.
Genes & development - 1 Jul 1991
LaRochelle W J, May-Siroff M, Robbins K C, Aaronson S A
Abstract excerpt
Platelet-derived growth factor (PDGF) chimeras were used to map a domain responsible for either efficient secretion of PDGF-A or the tight cell association of PDGF-B to their carboxy-terminal domains. Introduction of stop codons within PDGF-A or PDGF-B further dissected their respective carboxy-terminal domains. Although successive deletions of the PDGF-A carboxyl terminus did not impair its secretion,...
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