Article
A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain.
Genes & development - 1 Jul 1991
LaRochelle W J, May-Siroff M, Robbins K C, Aaronson S A
Abstract excerpt
Platelet-derived growth factor (PDGF) chimeras were used to map a domain responsible for either efficient secretion of PDGF-A or the tight cell association of PDGF-B to their carboxy-terminal domains. Introduction of stop codons within PDGF-A or PDGF-B further dissected their respective carboxy-terminal domains. Although successive deletions of the PDGF-A carboxyl terminus did not impair its secretion,...
Topics
- Amino Acid Sequence
- Animals
- Cell Membrane
- Chimera
- Hydrolysis
- Membrane Proteins
- Mice
- Molecular Sequence Data
- Mutation
- Peptide Mapping
- Platelet-Derived Growth Factor