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Article

Structural coincidence of alpha PDGFR epitopes binding to platelet-derived growth factor-AA and a potent neutralizing monoclonal antibody.

The Journal of biological chemistry - 8 Apr 1994

Yu J C, Mahadevan D, LaRochelle W J, Pierce J H, Heidaran M A

Abstract excerpt

We have generated two groups of deletion mutants of the alpha PDGFR and one group of chimeras between alpha PDGFR and beta PDGFR to further investigate the structural requirements of the alpha PDGFR for binding to platelet-derived growth factor (PDGF)-AA and to a monoclonal antibody against alpha PDGFR (designated as mAb-alpha R1). The mAb-alpha R1 has recently been reported to block high affinity binding of...

Topics

3T3 Cells
Animals
Antibodies, Monoclonal
Base Sequence
Epitopes
Humans
Immunoglobulins
Mice
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Platelet-Derived Growth Factor

Protein Binding

Receptors, Platelet-Derived Growth Factor

Sequence Deletion

Source

Identifiers

PMID: 7511602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7511602-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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