Directional selection associated with clonal expansion of p53 mutant cells during neoplastic development of carcinogen-treated rat embryo lung epithelial cells.

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Article

Directional selection associated with clonal expansion of p53 mutant cells during neoplastic development of carcinogen-treated rat embryo lung epithelial cells.

Oncogene - 1 Jan 1994

Le Rhun Y, Duthu A, Ehrhart J C, Michiels F, May E, May P

Abstract excerpt

In this study, rat embryo lung organ cultures were exposed to benzo[a]pyrene (B[a]P). After carcinogen-treatment the cells were dissociated and an epithelial cell line (BP) was developed from the primary cell culture derived from the carcinogen-treated explants. Investigations were performed on t...

Topics

Animals
Base Sequence
Benzo(a)pyrene
Embryo, Mammalian
Genes, p53
Lung
Molecular Sequence Data
Mutation
Neoplasms, Experimental
Organ Culture Techniques
Rats
Rats, Wistar

Source

Open in PubMed

Identifiers

PMID: 8302588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8302588-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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