Article
p53 mutations and tetraploids under r- and K-selection.
Oncogene - 2 May 2002
Chikatsu Norio, Nakamura Yukari, Sato Hiroyuki, Fujita Toshiro, Asano Shigetaka, Motokura Toru
Abstract excerpt
Cotransfection of rat embryo fibroblasts with c-myc and activated H-ras oncogenes is one experimental model of the multistep oncogenesis associated with p53 mutations and aneuploidy. Using the model, we found that selection processes, e.g., r- and K-selection, affect emergence of p53 mutants and tetraploids. Culture optimum for logarithmic growth (r-selection) selected p53 mutants as they proliferated rapidly,...
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