c-Ha-ras gene mutation and activation precede pathological changes in DMBA-induced in vivo carcinogenesis.

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Article

c-Ha-ras gene mutation and activation precede pathological changes in DMBA-induced in vivo carcinogenesis.

Oncogene - 1 Aug 1992

Kwong Y Y, Husain Z, Biswas D K

Abstract excerpt

We have previously reported a stage-specific and sequential overexpression of the c-Ha-ras and c-erbB genes in 7, 12-dimethylbenzanthracene (DMBA)-induced in vivo carcinogenesis in hamster buccal pouch epithelium (HBPE). In this investigation, the immunoreactive protein product of the c-Ha-ras gene (p21 protein) was identified in HBPE cells, specifically in treated tissues and cultured cells established after 3...

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Base Sequence
Cell Transformation, Neoplastic
Cricetinae
ErbB Receptors
Fluorescent Antibody Technique
Gene Expression Regulation, Neoplastic
Genes, ras
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Proto-Oncogene Proteins p21(ras)

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1630811

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1630811-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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