Article
c-Ha-ras gene mutation and activation precede pathological changes in DMBA-induced in vivo carcinogenesis.
Oncogene - 1 Aug 1992
Kwong Y Y, Husain Z, Biswas D K
Abstract excerpt
We have previously reported a stage-specific and sequential overexpression of the c-Ha-ras and c-erbB genes in 7, 12-dimethylbenzanthracene (DMBA)-induced in vivo carcinogenesis in hamster buccal pouch epithelium (HBPE). In this investigation, the immunoreactive protein product of the c-Ha-ras gene (p21 protein) was identified in HBPE cells, specifically in treated tissues and cultured cells established after 3...
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