Article
p53 mutations in mouse mammary epithelial cells: instability in culture and discordant selection of mutations in vitro versus in vivo.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1993
Ozbun M A, Medina D, Butel J S
Abstract excerpt
The phenotypes of p53 mutations found in human and murine tumors often are analyzed using a variety of transformation assays in vitro, but data have not been available to correlate in vitro effects with in vivo activities. We have assessed the effects of p53 mutations using mouse mammary epitheli...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Division
- Cells, Cultured
- Epithelial Cells
- Epithelium
- Female
- Hyperplasia
- Mammary Glands, Animal
- Mammary Neoplasms, Experimental
- Mice
- Molecular Sequence Data
- Mutation
- Neoplasm Transplantation
- Phenotype
- Protein Conformation