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Article

Spontaneous neoplastic transformation of WB-F344 rat liver epithelial cells.

The American journal of pathology - 1 Dec 1998

Hooth M J, Coleman W B, Presnell S C, Borchert K M, Grisham J W, Smith G J

Abstract excerpt

Several studies have shown that cultured rat liver epithelial cells transform spontaneously after chronic maintenance in a confluent state in vitro. In the present study, multiple independent lineages of low-passage WB-F344 rat liver epithelial stem-like cells were initiated and subjected in parallel to selection for spontaneous transformation to determine whether spontaneous acquisition of tumorigenicity was the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9846981
DOI: 10.1016/S0002-9440(10)65705-7
PMCID: PMC1866323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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