Article
Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.
Cellular immunology - 1 Jan 2009
Bishop Kenneth D, Harris John E, Mordes John P, Greiner Dale L, Rossini Aldo A, Czech Michael P, Phillips Nancy E
Abstract excerpt
Recent studies have implicated the cell surface receptor Programmed Death-1 (PD-1) in numerous models of T cell anergy, though the specific mechanisms by which the PD-1 signal maintains tolerance is not clear. We demonstrate that the depletion of PD-1 with siRNA results in a complete reversal of clonal anergy in the A.E7 T cell model, suggesting that the mechanism by which PD-1 maintains the anergic phenotype is...
Topics
- Animals
- Antigens
- Antigens, Surface
- Apoptosis Regulatory Proteins
- Base Sequence
- CD4-Positive T-Lymphocytes
- Cell Line
- Cell Proliferation
- Clonal Anergy
- Columbidae