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Article

Persistence of peptide-induced CD4+ T cell anergy in vitro.

The Journal of experimental medicine - 5 Jan 1998

Ryan K R, Evavold B D

Abstract excerpt

Clonal T cell unresponsiveness, or anergy, has been proposed as a mechanism of peripheral tolerance in vivo, and as a potential means of curbing unwanted T cell responses. In this study, anergy was induced in a T helper cell (Th) clone reactive to hemoglobin (Hb) peptide 64-76 by coculture of the...

Topics

Amino Acid Sequence
Animals
Antigen-Presenting Cells
CD4-Positive T-Lymphocytes
Clonal Anergy
Down-Regulation
Hemoglobins
In Vitro Techniques
Interleukin-12
Interleukin-2
Lymphocyte Activation
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Fragments

Peptides

Phenotype

Receptor-CD3 Complex, Antigen, T-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 9419214
DOI: 10.1084/jem.187.1.89
PMCID: PMC2199180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9419214-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Persistence of peptide-induced CD4+ T cell anergy in vitro.PMID 9419214Read ↗

A unique unresponsive CD4+ T cell phenotype post TCR antagonism.Semantic proximity Read ↗

Induction and stability of the anergic phenotype in T cells.Semantic proximity Read ↗

Dynamic adoption of anergy by antigen-exhausted CD4+ T cellsSemantic proximity Read ↗

In vivo antagonism of a T cell response by an endogenously expressed ligand.Semantic proximity Read ↗

T-cell anergy: from phenotype to genotype and back.Semantic proximity Read ↗

Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunitySemantic proximity Read ↗

"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.Semantic proximity Read ↗

Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.Semantic proximity Read ↗

Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.Semantic proximity Read ↗

Superantigen-reactive T cells that display an anergic phenotype in vitro appear functional in vivo.Semantic proximity Read ↗

The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.Semantic proximity Read ↗

CD28 mRNA rapidly decays when activated T cells are functionally anergized with specific peptide.Semantic proximity Read ↗

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