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Article

Persistence of peptide-induced CD4+ T cell anergy in vitro.

The Journal of experimental medicine - 5 Jan 1998

Ryan K R, Evavold B D

Abstract excerpt

Clonal T cell unresponsiveness, or anergy, has been proposed as a mechanism of peripheral tolerance in vivo, and as a potential means of curbing unwanted T cell responses. In this study, anergy was induced in a T helper cell (Th) clone reactive to hemoglobin (Hb) peptide 64-76 by coculture of the T cells with live antigen-presenting cells (APCs) and 74L, a peptide analog of Hb(64-76) that contains a single amino...

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Identifiers

PMID: 9419214
DOI: 10.1084/jem.187.1.89
PMCID: PMC2199180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Persistence of peptide-induced CD4+ T cell anergy in vitro.PMID 9419214Read ↗

A unique unresponsive CD4+ T cell phenotype post TCR antagonism.Semantic proximity Read ↗

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In vivo antagonism of a T cell response by an endogenously expressed ligand.Semantic proximity Read ↗

T-cell anergy: from phenotype to genotype and back.Semantic proximity Read ↗

Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunitySemantic proximity Read ↗

"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.Semantic proximity Read ↗

Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.Semantic proximity Read ↗

Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.Semantic proximity Read ↗

Superantigen-reactive T cells that display an anergic phenotype in vitro appear functional in vivo.Semantic proximity Read ↗

The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.Semantic proximity Read ↗

CD28 mRNA rapidly decays when activated T cells are functionally anergized with specific peptide.Semantic proximity Read ↗

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