Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure.

doi:10.1002/mc.2940040607

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Article

Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure.

Molecular carcinogenesis - 1 Jan 1991

Marion M J, Froment O, Trépo C

Abstract excerpt

Point mutations of c-ras genes were investigated in human angiosarcomas of the liver associated with occupational exposure to vinyl chloride. DNA prepared from either frozen or paraffin-embedded tissues was amplified by the polymerase chain reaction, and putative point mutations at codons 12, 13,...

Topics

Base Sequence
France
Genes, ras
Hemangiosarcoma
Humans
Liver Neoplasms
Molecular Sequence Data
Mutation
Occupational Diseases
Oligonucleotide Probes
Oncogenes
Proto-Oncogene Proteins p21(ras)
Time Factors
Vinyl Chloride

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