Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vinyl chloride-specific mutations in humans and animals.

IARC scientific publications - 1 Jan 1999

Marion M J, Boivin-Angele S

Abstract excerpt

Vinyl chloride is a potent hepatocarcinogen which reacts with DNA to generate etheno bases. In order to determine whether mutational patterns in target genes in vivo are characteristic of vinyl chloride and could be explained by the mutagenic properties of the etheno bases, human and rat liver tumours associated with exposure to vinyl chloride were analysed for point mutations in the ras and p53 genes. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver Neoplasms
Share to Carcinogens
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, ras

Share to Hemangiosarcoma

Share to Liver Neoplasms, Experimental

Share to Polymorphism, Single-Stranded Conformational

Share to Rats, Sprague-Dawley

Source

Identifiers

PMID: 10626231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vinyl chloride-specific mutations in humans and animals.PMID 10626231Read ↗

ras gene mutations in vinyl chloride-induced liver tumours are carcinogen-specific but vary with cell type and speciesSemantic proximity Read ↗

Etheno-adduct-forming chemicals: from mutagenicity testing to tumor mutation spectra.Semantic proximity Read ↗

High prevalence of K-ras-2 mutations in hepatocellular carcinomas in workers exposed to vinyl chloride.Semantic proximity Read ↗

p53 mutation pattern in hepatocellular carcinoma in workers exposed to vinyl chloride.Semantic proximity Read ↗

p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers.Semantic proximity Read ↗

Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure.Semantic proximity Read ↗

Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride.Semantic proximity Read ↗

Frequent k- ras -2 mutations and p16INK4Amethylation in hepatocellular carcinomas in workers exposed to vinyl chlorideSemantic proximity Read ↗

Formation of DNA etheno adducts in rodents and humans and their role in carcinogenesis.Semantic proximity Read ↗

Mutation spectra resulting from carcinogenic exposure: from model systems to cancer-related genes.Semantic proximity Read ↗

Mutant c-Ki-ras p21 protein in chemical carcinogenesis in humans exposed to vinyl chloride.Semantic proximity Read ↗

Role of etheno DNA adducts in carcinogenesis induced by vinyl chloride in rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.