p53 mutation pattern in hepatocellular carcinoma in workers exposed to vinyl chloride.

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Article

p53 mutation pattern in hepatocellular carcinoma in workers exposed to vinyl chloride.

Cancer - 1 Mar 2000

Weihrauch M, Lehnert G, Köckerling F, Wittekind C, Tannapfel A

Abstract excerpt

BACKGROUND: Vinyl chloride (VC) is a known animal and human carcinogen that is associated with liver angiosarcoma and most likely also with hepatocellular carcinoma (HCC) in humans. METHODS: The authors examined the presence of p53 gene mutations in 18 HCC specimens from patients with known exposure to VC (median, 8883 parts per million-years; median duration, 245 months). In all cases, other risk factors for the...

Topics

Aged
Amino Acid Substitution
Carcinogens
Carcinoma, Hepatocellular
Genes, p53
Humans
Liver Neoplasms
Middle Aged
Mutation
Occupational Exposure
Point Mutation
Vinyl Chloride

Source

Open in PubMed

Identifiers

PMID: 10699891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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