Article
High prevalence of K-ras-2 mutations in hepatocellular carcinomas in workers exposed to vinyl chloride.
International archives of occupational and environmental health - 1 Aug 2001
Weihrauch M, Benick M, Lehner G, Wittekind M, Bader M, Wrbitzk R, Tannapfel A
Abstract excerpt
OBJECTIVES: Vinyl chloride (VC) and its metabolites are human carcinogens associated with liver angiosarcomas (LAS) and also with hepatocellular carcinomas (HCCs). In VC associated LAS mutations of the K-ras-2 gene have been reported, however, no data about the prevalence of such mutations in VC-associated HCCs are available. The aim of the study was to evaluate possible specific K-ras-2 oncogene mutations in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.