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Article

Mutant c-Ki-ras p21 protein in chemical carcinogenesis in humans exposed to vinyl chloride.

Cancer causes & control : CCC - 1 May 1994

De Vivo I, Marion M J, Smith S J, Carney W P, Brandt-Rauf P W

Abstract excerpt

Mutations in ras oncogenes and expression of their encoded p21 protein products are believed to play an important role in carcinogenesis in humans. Detection of mutant p21 proteins in serum may be a useful molecular epidemiologic biomarker with which to study this process, and workers with heavy exposure to vinyl chloride (VC) represent a model population for such study. We studied the occurrence of a specific...

Topics

Aged
Biomarkers, Tumor
Carcinogens
Codon
Cohort Studies
Gene Expression Regulation, Neoplastic
Hemangiosarcoma
Humans
Liver
Liver Neoplasms
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Occupational Diseases

Precancerous Conditions

Proto-Oncogene Proteins p21(ras)

Vinyl Chloride

Source

Identifiers

PMID: 8061177
DOI: 10.1007/BF01830248

Genes

ASL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8061177-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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