Article
Molecular epidemiology of p53 protein mutations in workers exposed to vinyl chloride.
American journal of epidemiology - 1 Feb 1998
Smith S J, Li Y, Whitley R, Marion M J, Partilo S, Carney W P, Brandt-Rauf P W
Abstract excerpt
The production of mutations in cellular tumor suppressor genes such as p53 is involved in the development of many human cancers. These mutations result in the expression of mutant forms of the encoded p53 protein which can potentially serve as a biomarker for this carcinogenic process. Workers ex...
Topics
- Adult
- Aged
- Antibodies, Neoplasm
- Biomarkers, Tumor
- Carcinogens
- Enzyme-Linked Immunosorbent Assay
- France
- Hemangiosarcoma
- Humans
- Incidence
- Liver Neoplasms
- Male
- Middle Aged
- Molecular Epidemiology
- Mutation
- Occupational Diseases
- Occupational Exposure
- Retrospective Studies