Article
Validity of saliva samples for the estimation of dipyrone metabolites pharmacokinetics.
Arzneimittel-Forschung - 1 Nov 1993
Caraco Y, Zylber-Katz E, Granit L, Levy M
Abstract excerpt
Plasma and saliva pharmacokinetics of dipyrone (CAS 5907-38-0) metabolites, 4-methylaminoantipyrine (MAA), 4-aminoantipyrine (AA), 4-formylaminoantipyrine (FAA) and 4-acetylaminoantipyrine (AAA), has been studied in 10 healthy volunteers, after oral administration of 1.0 g dipyrone, MAA, AA, FAA and AAA saliva concentrations correlated significantly with the respective plasma concentrations (r = 0.81, r = 0.62, r...
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