Clinical pharmacokinetics of dipyrone and its metabolites.

doi:10.2165/00003088-199528030-00004

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Article

Clinical pharmacokinetics of dipyrone and its metabolites.

Clinical pharmacokinetics - 1 Mar 1995

Levy M, Zylber-Katz E, Rosenkranz B

Abstract excerpt

The pharmacokinetics of dipyrone are characterised by rapid hydrolysis to the active moiety 4-methyl-amino-antipyrine (MAA), which has 85% bioavailability after oral administration in tablet form, and takes a short time to achieve maximal systemic concentrations (tmax of 1.2 to 2.0 hours). Absolu...

Topics

Acetylation
Administration, Oral
Dipyrone
Drug Interactions
Female
Humans
Kidney Diseases
Liver Diseases
Male
Phenotype
Pregnancy

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