Article
Clinical pharmacokinetics of dipyrone and its metabolites.
Clinical pharmacokinetics - 1 Mar 1995
Levy M, Zylber-Katz E, Rosenkranz B
Abstract excerpt
The pharmacokinetics of dipyrone are characterised by rapid hydrolysis to the active moiety 4-methyl-amino-antipyrine (MAA), which has 85% bioavailability after oral administration in tablet form, and takes a short time to achieve maximal systemic concentrations (tmax of 1.2 to 2.0 hours). Absolute bioavailability after intramuscular and rectal administration is 87 and 54%, respectively. MAA is further...
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