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Article

Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow acetylator inbred rat liver.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Hein D W, Rustan T D, Bucher K D, Martin W J, Furman E J

Abstract excerpt

Although mouse, hamster, and rabbit models of the human N-acetylation polymorphism have been identified and characterized, many investigations of arylamine toxicity and carcinogenicity are carried out in the rat, particularly the Fischer 344 (F-344) inbred rat. We partially characterized a new rat model of the N-acetylation polymorphism by determining expression of arylamine N-acetyltransferase activities in...

Topics

Acetylation
Animals
Arylamine N-Acetyltransferase
Cytosol
Isoenzymes
Liver
Male
Phenotype
Polymorphism, Genetic
Rats
Rats, Inbred F344

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred WKY

Time Factors

Source

Identifiers

PMID: 1686239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1686239-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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