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Article

Extrahepatic expression of N-acetylator genotype in the inbred hamster.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Hein D W, Kirlin W G, Ogolla F, Trinidad A

Abstract excerpt

The genetic control of S-acetylcoenzyme A (AcCoA)-dependent N-acetyltransferase activity (EC 2.3.1.5) was investigated in liver, intestine, kidney, and lung cytosols derived from homozygous rapid acetylator (Bio. 87.20), heterozygous acetylator (Bio. 87.20 X 82.73/H F1), and homozygous slow acety...

Topics

Acetylation
Acetyltransferases
Animals
Arylamine N-Acetyltransferase
Cricetinae
Cytosol
Gene Expression Regulation
Genotype
In Vitro Techniques
Intestines
Kidney
Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lung

Mesocricetus

Polymorphism, Genetic

Substrate Specificity

Source

Identifiers

PMID: 2881761

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2881761-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Extrahepatic expression of N-acetylator genotype in the inbred hamster.PMID 2881761Read ↗

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Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus.Semantic proximity Read ↗

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