Article
Extrahepatic expression of N-acetylator genotype in the inbred hamster.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Hein D W, Kirlin W G, Ogolla F, Trinidad A
Abstract excerpt
The genetic control of S-acetylcoenzyme A (AcCoA)-dependent N-acetyltransferase activity (EC 2.3.1.5) was investigated in liver, intestine, kidney, and lung cytosols derived from homozygous rapid acetylator (Bio. 87.20), heterozygous acetylator (Bio. 87.20 X 82.73/H F1), and homozygous slow acetylator (Bio. 82.73/H) Syrian inbred hamsters. AcCoA-dependent N-acetyltransferase activity was highest in hepatic...
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