Article
A Chinese hamster ovary cell mutant (EM-C11) with sensitivity to simple alkylating agents and a very high level of sister chromatid exchanges.
Mutagenesis - 1 Jul 1992
Zdzienicka M Z, van der Schans G P, Natarajan A T, Thompson L H, Neuteboom I, Simons J W
Abstract excerpt
We have isolated a Chinese hamster ovary cell mutant hypersensitive to monofunctional alkylating agents. The mutant, designed as EM-C11, showed hypersensitivity to ethyl methanesulfonate (EMS), methyl methanesulfonate and ethylnitrosourea (8-, 7- and 2-fold, respectively, based on D10 values). Ab...
Topics
- Alkylating Agents
- Animals
- CHO Cells
- Cell Survival
- Chromosome Aberrations
- Cricetinae
- DNA Damage
- DNA Repair
- Female
- Genetic Complementation Test
- Mutation
- Ovary
- Sister Chromatid Exchange