Article
An 'elaborated' pseudoknot is required for high frequency frameshifting during translation of HCV 229E polymerase mRNA.
Nucleic acids research - 25 Dec 1993
Herold J, Siddell S G
Abstract excerpt
The RNA polymerase gene (gene 1) of the human coronavirus 229E is approximately 20 kb in length and is located at the 5' end of the positive-strand genomic RNA. The coding sequence of gene 1 is divided into two large open reading frames, ORF1a and ORF1b, that overlap by 43 nucleotides. In the reg...
Topics
- Amino Acid Sequence
- Base Composition
- Base Sequence
- Coronavirus
- Coronavirus 229E, Human
- DNA
- DNA-Directed RNA Polymerases
- Frameshift Mutation
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Nucleic Acid Conformation