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Article

Functional analysis of the SRV-1 RNA frameshifting pseudoknot.

Nucleic acids research - 1 Nov 2010

Olsthoorn René C L, Reumerman Richard, Hilbers Cornelis W, Pleij Cornelis W A, Heus Hans A

Abstract excerpt

Simian retrovirus type-1 uses programmed ribosomal frameshifting to control expression of the Gag-Pol polyprotein from overlapping gag and pol open-reading frames. The frameshifting signal consists of a heptanucleotide slippery sequence and a downstream-located 12-base pair pseudoknot. The solution structure of this pseudoknot, previously solved by NMR [Michiels,P.J., Versleijen,A.A., Verlaan,P.W., Pleij,C.W.,...

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Source

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Identifiers

PMID: 20639537
DOI: 10.1093/nar/gkq629
PMCID: PMC2995055

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