Article
Identification of Hepta- and Octo-Uridine stretches as sole signals for programmed +1 and -1 ribosomal frameshifting during translation of SARS-CoV ORF 3a variants.
Nucleic acids research - 1 Jan 2006
Wang Xiaoxing, Wong Sek-Man, Liu D X
Abstract excerpt
Programmed frameshifting is one of the translational recoding mechanisms that read the genetic code in alternative ways. This process is generally programmed by signals at defined locations in a specific mRNA. In this study, we report the identification of hepta- and octo-uridine stretches as sole signals for programmed +1 and -1 ribosomal frameshifting during translation of severe acute respiratory syndrome...
Topics
- Animals
- COS Cells
- Chlorocebus aethiops
- Frameshifting, Ribosomal
- Genetic Variation
- Mutation
- Open Reading Frames
- RNA, Messenger
- RNA, Viral
- Regulatory Sequences, Ribonucleic Acid
- Severe acute respiratory syndrome-related coronavirus