Establishment of a cell line with AML1-MTG8, TP53, and TP73 abnormalities from acute myelogenous leukemia.

doi:10.1002/gcc.1181

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Article

Establishment of a cell line with AML1-MTG8, TP53, and TP73 abnormalities from acute myelogenous leukemia.

Genes, chromosomes & cancer - 1 Oct 2001

Inokuchi K, Hamaguchi H, Taniwaki M, Yamaguchi H, Tanosaki S, Dan K

Abstract excerpt

Gene alterations accumulate during the progression of acute myelogenous leukemia (AML) to a malignant clone. Here, a new myeloid cell line, designated YSK-21, with the balanced t(8;21)(q22;q22) and the unbalanced der(1)t(1;17)(p36;q21), was established. YSK-21 grows well in a medium containing recombinant human granulocyte colony-stimulating factor (rhG-CSF), granulocyte-macrophage colony-stimulating factor...

Topics

Cell Culture Techniques
Core Binding Factor Alpha 2 Subunit
Genes, p53
Humans
Karyotyping
Leukemia, Myeloid, Acute
Male
Middle Aged
Mutation
Oncogene Proteins, Fusion
RUNX1 Translocation Partner 1 Protein
Transcription Factors
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 11550287
DOI: 10.1002/gcc.1181

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