Article
Mutation of the p53 gene in human acute myelogenous leukemia.
Blood - 1 Apr 1991
Slingerland J M, Minden M D, Benchimol S
Abstract excerpt
Heterogeneity of p53 protein expression is seen in blast cells of patients with acute myelogenous leukemia (AML). p53 protein is detected in the blasts of certain AML patients but not in others. We have identified p53 protein variants with abnormal mobility on gel electrophoresis and/or prolonged half-life (t 1/2). We have sequenced the p53 coding sequence from primary blast cells of five AML patients and from...
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