Mutation of the p53 gene in human acute myelogenous leukemia.

Article

Mutation of the p53 gene in human acute myelogenous leukemia.

Blood - 1 Apr 1991

Slingerland J M, Minden M D, Benchimol S

Abstract excerpt

Heterogeneity of p53 protein expression is seen in blast cells of patients with acute myelogenous leukemia (AML). p53 protein is detected in the blasts of certain AML patients but not in others. We have identified p53 protein variants with abnormal mobility on gel electrophoresis and/or prolonged...

Topics

Base Sequence
Blast Crisis
Blotting, Western
Cell Line
DNA, Neoplasm
Humans
Leukemia, Myeloid, Acute
Models, Genetic
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Oligonucleotides, Antisense
Polymerase Chain Reaction
Tumor Cells, Cultured
Tumor Suppressor Protein p53

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