Article

Mutation of the p53 gene in human acute myelogenous leukemia

1991-04-01

Abstract excerpt

Abstract Heterogeneity of p53 protein expression is seen in blast cells of patients with acute myelogenous leukemia (AML). p53 protein is detected in the blasts of certain AML patients but not in others. We have identified p53 protein variants with abnormal mobility on gel electrophoresis and/or prolonged half-life (t 1/2). We have sequenced the p53 coding sequence from primary blast cells of five AML patients and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6b05717f-ce11-5a6a-9304-8b510a9ba3b0
DOI: 10.1182/blood.v77.7.1500.1500

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutation of the p53 gene in human acute myelogenous leukemiaDOI 10.1182/blood.v77.7.1500.1500Read

Mutation of the p53 gene in human acute myelogenous leukemia.Semantic proximity Read

p53 in chronic myeloid leukemia cell lines.Semantic proximity Read

Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53.Semantic proximity Read

Analysis of p53 gene mutations in acute myeloid leukemia.Semantic proximity Read

Genetic alterations in the p53 gene in the blast crisis of chronic myelogenous leukemia: analysis by polymerase chain reaction based techniques.Semantic proximity Read

Mutational inactivation of the p53 gene in the human erythroid leukemic K562 cell line.Semantic proximity Read

Frequent mutations in the p53 gene in human myeloid leukemia cell lines.Semantic proximity Read

Altered conformation of the p53 protein in myeloid leukemia cells and mitogen-stimulated normal blood cells.Semantic proximity Read

Frequent mutations in the p53 gene in human myeloid leukemia cell linesSemantic proximity Read

The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia.Semantic proximity Read

A splicing mutation accounts for the lack of p53 gene expression in a CML blast crisis cell line: a novel mechanism of p53 gene inactivation.Semantic proximity Read

Total loss of p53 DNA sequences in acute myeloid leukemia.Semantic proximity Read