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Article

E1A represses wild-type and F9-selected polyomavirus DNA replication by a mechanism not requiring depression of large tumor antigen transcription.

Journal of virology - 1 Jun 1991

DePolo N J, Villarreal L P

Abstract excerpt

Polyomavirus (Py) DNA replication may be regulated to a low-level replication state in specific target cells in mice as well as in certain undifferentiated murine cell lines, such as embryocarcinoma (EC) cells. To investigate possible mechanisms by which such control may occur, we have examined the effects of E1A on Py DNA replication. Adenovirus E1A proteins repress transcriptional activation of various...

Topics

Adenovirus Early Proteins
Animals
Antigens, Viral, Tumor
DNA Replication
DNA, Viral
Enhancer Elements, Genetic
Gene Expression Regulation, Viral
Genetic Variation
Oncogene Proteins, Viral
Plasmids
Polyomavirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Repressor Proteins

Transfection

Tumor Cells, Cultured

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1851864
DOI: 10.1128/JVI.65.6.2921-2928.1991
PMCID: PMC240926

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1851864-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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