Reduced Polyomavirus DNA replication as a consequence of a late-region deletion that results in early mRNA instability.

doi:10.1016/0168-1702(91)90106-6

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Article

Reduced Polyomavirus DNA replication as a consequence of a late-region deletion that results in early mRNA instability.

Virus research - 1 Jul 1991

Risuleo G, Melucci-Vigo G, Magnusson G

Abstract excerpt

A Polyomavirus mutant with a 504 base pair deletion downstream of the polyadenylation signal for the early genes was constructed in vitro. This mutant showed a reduced synthesis of viral DNA. In cotransfection experiments, this defect was complemented by the presence of a wild-type genome. To def...

Topics

Base Sequence
Chromosome Deletion
DNA Replication
DNA, Viral
Genes, Viral
Molecular Sequence Data
Mutation
Polyomavirus
RNA, Messenger
RNA, Viral

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