Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Host range specificity of polyomavirus EC mutants in mouse embryonal carcinoma and embryonal stem cells and preimplantation embryos.

Journal of virology - 1 Jun 1991

Mélin F, Kemler R, Kress C, Pinon H, Blangy D

Abstract excerpt

New polyomavirus mutants (PyEC-C) selected on LT1 cells and exhibiting a strong cytopathic effect in all embryonal carcinoma (EC) cell lines tested have been isolated. They were derived by a sequence duplication event from a new multiadapted mutant isolated in PCC4 cells. A quantitative analysis of viral DNA replication and transcription in 3T6 and EC cell lines was performed to compare PyEC-C mutants and PyEC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Viral
Share to Gene Expression
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mutation

Share to Plasmids

Share to Pregnancy

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1851869
DOI: 10.1128/JVI.65.6.3029-3043.1991
PMCID: PMC240958

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Host range specificity of polyomavirus EC mutants in mouse embryonal carcinoma and embryonal stem cells and preimplantation embryos.PMID 1851869Read ↗

Mutations of polyomavirus VP1 allow in vitro growth in undifferentiated cells and modify in vivo tissue replication specificity.Semantic proximity Read ↗

Transcription enhancer factor-1 (TEF-1) DNA binding sites can specifically enhance gene expression at the beginning of mouse development.Semantic proximity Read ↗

Reduced Polyomavirus DNA replication as a consequence of a late-region deletion that results in early mRNA instability.Semantic proximity Read ↗

A mutation in the DE loop of the VP1 protein that prevents polyomavirus transcription and replication.Semantic proximity Read ↗

Enhancer-mediated role for polyomavirus middle T/small T in DNA replication.Semantic proximity Read ↗

E1A represses wild-type and F9-selected polyomavirus DNA replication by a mechanism not requiring depression of large tumor antigen transcription.Semantic proximity Read ↗

A factor discriminating between the wild-type and a mutant polyomavirus enhancer.Semantic proximity Read ↗

Viral genomes maintained extrachromosomally in hamster polyomavirus-induced lymphomas display a cell-specific replication in vitro.Semantic proximity Read ↗

Identification of a DNA encapsidation sequence for human polyomavirus pseudovirion formation.Semantic proximity Read ↗

Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus.Semantic proximity Read ↗

Analysis of a nontumorigenic embryonal carcinoma cell line.Semantic proximity Read ↗

Independent contributions of polyomavirus middle T and small T to the regulation of early and late gene expression and DNA replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.