Article
A mutation in the DE loop of the VP1 protein that prevents polyomavirus transcription and replication.
Virology - 5 Jul 2000
Garcia M I, Perez M, Caruso M, Sthandier O, Ferreira R, Cermola M, Macchia C, Amati P
Abstract excerpt
Natural mutants of the DE loop of the Polyomavirus (Py) major coat protein VP1 have been previously shown to display an altered host specificity (L. Ricci, R. Maione, C. Passananti, A. Felsani, and P. Amati, 1992, J. Virol. 66, 7153-7158). To better understand the role of this outfacing loop of the VP1 protein in Py infectivity, we constructed and characterized a Py mutant (Py M17) harboring a deletion of 7 AA...
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