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Article

A factor discriminating between the wild-type and a mutant polyomavirus enhancer.

Nature - 1 Jan 2000

Kovesdi I, Satake M, Furukawa K, Reichel R, Ito Y, Nevins J R

Abstract excerpt

Enhancers increase the frequency of transcription initiation from linked promoter elements, most probably as a result of the binding of specific proteins to the enhancer. The polyomavirus early region is expressed in differentiated mouse cells but not in undifferentiated embryonal carcinoma (EC) cells. This host range is a function of the enhancer because polyomavirus mutants selected for growth in EC cells have...

Topics

Animals
Base Sequence
Binding Sites
Cell Line
DNA, Recombinant
DNA, Viral
Enhancer Elements, Genetic
Genes, Regulator
Mutation
Oligodeoxyribonucleotides
Polyomavirus
Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Teratoma

Source

Identifiers

PMID: 3037380
DOI: 10.1038/328087a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3037380-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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