Article
A mutated polyoma virus enhancer which is active in undifferentiated embryonal carcinoma cells is not repressed by adenovirus-2 E1A products.
Nature - 1 Jan 2000
Hen R, Borrelli E, Fromental C, Sassone-Corsi P, Chambon P
Abstract excerpt
Enhancers stimulate transcription of several eukaryotic genes (for review see ref. 1). While some enhancers, like that of simian virus 40 (SV40), are active in a wide range of cell types, others are more cell-specific. For example, the polyoma virus (Py) enhancer is not active in undifferentiated...
Topics
- Adenovirus Early Proteins
- Animals
- Cell Differentiation
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Genes, Regulator
- Mice
- Mutation
- Oncogene Proteins, Viral
- Polyomavirus
- Repressor Proteins
- Teratoma