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Article

Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila.

Genes & development - 1 Jan 1994

Bone J R, Lavender J, Richman R, Palmer M J, Turner B M, Kuroda M I

Abstract excerpt

Dosage compensation in Drosophila occurs by an increase in transcription of genes on the X chromosome in males. This elevated expression requires the function of at least four loci, known collectively as the male-specific lethal (msl) genes. The proteins encoded by two of these genes, maleless (mle) and male-specific lethal-1 (msl-1), are found associated with the X chromosome in males, suggesting that they act...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8288132
DOI: 10.1101/gad.8.1.96

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila.PMID 8288132Read ↗

Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation.Semantic proximity Read ↗

Role of the male specific lethal (msl) genes in modifying the effects of sex chromosomal dosage in Drosophila.Semantic proximity Read ↗

Regulation of the sex-specific binding of the maleless dosage compensation protein to the male X chromosome in Drosophila.Semantic proximity Read ↗

Histone acetylation and gene expression analysis of sex lethal mutants in Drosophila.Semantic proximity Read ↗

Sex-specific regulation of the male-specific lethal-1 dosage compensation gene in Drosophila.Semantic proximity Read ↗

Dosage compensation in Drosophila: the X-chromosomal binding of MSL-1 and MLE is dependent on Sxl activity.Semantic proximity Read ↗

Gene expression analysis of the function of the male-specific lethal complex in Drosophila.Semantic proximity Read ↗

Evidence that MSL-mediated dosage compensation in Drosophila begins at blastoderm.Semantic proximity Read ↗

Molecular characterization of the male-specific lethal-3 gene and investigations of the regulation of dosage compensation in Drosophila.Semantic proximity Read ↗

Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males.Semantic proximity Read ↗

RNA-dependent association of the Drosophila maleless protein with the male X chromosome.Semantic proximity Read ↗

The Drosophila GAGA factor is required for dosage compensation in males and for the formation of the male-specific-lethal complex chromatin entry site at 12DE.Semantic proximity Read ↗

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