Article
Dosage compensation in Drosophila: the X-chromosomal binding of MSL-1 and MLE is dependent on Sxl activity.
The EMBO journal - 1 Aug 1994
Hilfiker A, Yang Y, Hayes D H, Beard C A, Manning J E, Lucchesi J C
Abstract excerpt
In Drosophila, dosage compensation, i.e. the equalization of levels of X-linked gene products in the two sexes, is achieved by the hypertranscription of most X-linked genes in males relative to females. The products of at least four genes, collectively termed male-specific lethal (msl) genes, are required for this process and, at least in the case of three of them, mediate this function through an association...
Read the complete abstract on PubMedTopics
- Animals
- Cell Nucleus
- Chromosomal Proteins, Non-Histone
- DNA
- DNA Helicases
- DNA-Binding Proteins
- Dosage Compensation, Genetic