Article
Dosage compensation in Drosophila: the X-chromosomal binding of MSL-1 and MLE is dependent on Sxl activity.
The EMBO journal - 1 Aug 1994
Hilfiker A, Yang Y, Hayes D H, Beard C A, Manning J E, Lucchesi J C
Abstract excerpt
In Drosophila, dosage compensation, i.e. the equalization of levels of X-linked gene products in the two sexes, is achieved by the hypertranscription of most X-linked genes in males relative to females. The products of at least four genes, collectively termed male-specific lethal (msl) genes, are...
Topics
- Animals
- Cell Nucleus
- Chromosomal Proteins, Non-Histone
- DNA
- DNA Helicases
- DNA-Binding Proteins
- Dosage Compensation, Genetic
- Drosophila
- Drosophila Proteins
- Female
- Genes, Insect
- Genes, Lethal
- Histones
- Insect Hormones
- Male
- Mutation
- Nuclear Proteins
- Protein Binding