Article
Gene expression analysis of the function of the male-specific lethal complex in Drosophila.
Genetics - 1 Apr 2005
Bhadra Manika Pal, Bhadra Utpal, Kundu Joydeep, Birchler James A
Abstract excerpt
Dosage compensation refers to the equal expression of X-linked genes despite the difference in copy number between the two sexes. The male-specific lethal (MSL) complex is concentrated on the X chromosome in males. A gene expression assay for embryos was developed to examine the function of this complex. In mutant male embryos without either the MSL complex or MOF histone acetylase, dosage compensation is...
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