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Article

Molecular characterization of the male-specific lethal-3 gene and investigations of the regulation of dosage compensation in Drosophila.

Development (Cambridge, England) - 1 Feb 1995

Gorman M, Franke A, Baker B S

Abstract excerpt

In Drosophila, dosage compensation occurs by transcribing the single male X chromosome at twice the rate of each of the two female X chromosomes. This hypertranscription requires four autosomal male-specific lethal (msl) genes and is negatively regulated by the Sxl gene in females. Two of the msls, the mle and msl-1 genes, encode proteins that are associated with hundreds of specific sites along the length of the...

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PMID: 7768187
DOI: 10.1242/dev.121.2.463

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Molecular characterization of the male-specific lethal-3 gene and investigations of the regulation of dosage compensation in Drosophila.PMID 7768187Read ↗

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Dosage compensation in Drosophila: the X-chromosomal binding of MSL-1 and MLE is dependent on Sxl activity.Semantic proximity Read ↗

Primary Sex Determination in Drosophila melanogaster Does Not Rely on the Male-Specific Lethal Complex.Semantic proximity Read ↗

Gene expression analysis of the function of the male-specific lethal complex in Drosophila.Semantic proximity Read ↗

The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex.Semantic proximity Read ↗

Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila.Semantic proximity Read ↗

Role of the male specific lethal (msl) genes in modifying the effects of sex chromosomal dosage in Drosophila.Semantic proximity Read ↗

RNA-dependent association of the Drosophila maleless protein with the male X chromosome.Semantic proximity Read ↗

Sequence signatures involved in targeting the Male-Specific Lethal complex to X-chromosomal genes in Drosophila melanogaster.Semantic proximity Read ↗

Drosophila maleless gene counteracts X global aneuploid effects in males.Semantic proximity Read ↗

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