Article
The relation between p53 mutation and p53 immunostaining in non-melanoma skin cancer.
The British journal of dermatology - 1 Sept 1993
Campbell C, Quinn A G, Angus B, Rees J L
Abstract excerpt
Extensive study of the p53 gene has established its role as a tumour-suppressor gene, and the involvement of mutant p53 in a wide spectrum of human malignancy. Many mutations of p53 result in a protein product that is abnormally stable, so that it becomes readily detectable by immunocytochemistry. In contrast, under normal conditions, it has been considered that levels of wild-type p53 were too low to be...
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