The relation between p53 mutation and p53 immunostaining in non-melanoma skin cancer.

doi:10.1111/j.1365-2133.1993.tb11840.x

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Article

The relation between p53 mutation and p53 immunostaining in non-melanoma skin cancer.

The British journal of dermatology - 1 Sept 1993

Campbell C, Quinn A G, Angus B, Rees J L

Abstract excerpt

Extensive study of the p53 gene has established its role as a tumour-suppressor gene, and the involvement of mutant p53 in a wide spectrum of human malignancy. Many mutations of p53 result in a protein product that is abnormally stable, so that it becomes readily detectable by immunocytochemistry...

Topics

Aged
Aged, 80 and over
Base Sequence
Bowen's Disease
Carcinoma, Basal Cell
Genes, p53
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Skin Neoplasms
Tumor Suppressor Protein p53

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