Article
The development and testing of retroviral vectors expressing trans-dominant mutants of HIV-1 proteins to confer anti-HIV-1 resistance.
Human gene therapy - 1 Oct 1993
Liem S E, Ramezani A, Li X, Joshi S
Abstract excerpt
Trans-dominant mutants of human immunodeficiency virus type 1 (HIV-1) Tat and Rev are attractive candidates for use in gene therapy in the treatment of HIV-1 infections because both are essential for viral replication. Retroviral vectors were constructed to allow either Tat-inducible or Tat- and...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Gene Products, rev
- Gene Products, tat
- Genes, Dominant
- Genetic Therapy
- Genetic Vectors
- HIV Infections
- HIV-1
- Mice
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- RNA, Messenger
- Retroviridae