Article
Analysis of trans-dominant mutants of the HIV type 1 Rev protein for their ability to inhibit Rev function, HIV type 1 replication, and their use as anti-HIV gene therapeutics.
AIDS research and human retroviruses - 1 Nov 1995
Ragheb J A, Bressler P, Daucher M, Chiang L, Chuah M K, VandenDriessche T, Morgan R A
Abstract excerpt
The HIV-1 rev gene product facilitates the transport of singly spliced and unspliced HIV-1 transcripts and is necessary for productive HIV-1 infection. On the basis of the previously described trans-dominant Rev mutant M10, four point mutants and one frameshift mutant of the Rev protein were cons...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Chloramphenicol O-Acetyltransferase
- Frameshift Mutation
- Gene Products, env
- Gene Products, rev
- Genes, Dominant
- Genes, Reporter
- Genetic Therapy
- HIV Infections
- HIV-1
- HeLa Cells