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Article

Suppression of simian immunodeficiency virus replication by human immunodeficiency virus type 1 trans-dominant negative rev mutants.

Journal of virology - 1 Aug 1995

Endres C L, Bergquam E P, Axthelm M K, Wong S W

Abstract excerpt

We demonstrate that trans-dominant negative rev mutants are able to suppress simian immunodeficiency virus provirus replication in both transient cotransfection assays and stably transduced HUT 78 cells. These studies suggest that the efficacy of trans-dominant rev strategies in reducing viral burden may be evaluated in a simian immunodeficiency virus-rhesus macaque animal model.

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Identifiers

PMID: 7609088
DOI: 10.1128/JVI.69.8.5164-5166.1995
PMCID: PMC189339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppression of simian immunodeficiency virus replication by human immunodeficiency virus type 1 trans-dominant negative rev mutants.PMID 7609088Read ↗

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The development and testing of retroviral vectors expressing trans-dominant mutants of HIV-1 proteins to confer anti-HIV-1 resistance.Semantic proximity Read ↗

Regulated expression of a dominant negative form of Rev improves resistance to HIV replication in T cells.Semantic proximity Read ↗

Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication.Semantic proximity Read ↗

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Modified human immunodeficiency virus-based lentiviral vectors display decreased sensitivity to trans-dominant Rev.Semantic proximity Read ↗

trans-dominant interference with human immunodeficiency virus type 1 replication and transmission in CD4(+) cells by an envelope double mutant.Semantic proximity Read ↗

Complementation of the rev gene mutation among human and simian lentiviruses.Semantic proximity Read ↗

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