Suppression of simian immunodeficiency virus replication by human immunodeficiency virus type 1 trans-dominant negative rev mutants.

doi:10.1128/JVI.69.8.5164-5166.1995

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Article

Suppression of simian immunodeficiency virus replication by human immunodeficiency virus type 1 trans-dominant negative rev mutants.

Journal of virology - 1 Aug 1995

Endres C L, Bergquam E P, Axthelm M K, Wong S W

Abstract excerpt

We demonstrate that trans-dominant negative rev mutants are able to suppress simian immunodeficiency virus provirus replication in both transient cotransfection assays and stably transduced HUT 78 cells. These studies suggest that the efficacy of trans-dominant rev strategies in reducing viral bu...

Topics

Amino Acid Sequence
Cell Line
Genes, Dominant
Genes, rev
Genetic Vectors
HIV-1
Humans
Molecular Sequence Data
Mutation
Simian Immunodeficiency Virus
Transduction, Genetic
Virus Replication

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