Article
Low frequency of retinoblastoma gene alterations in rat hepatocellular carcinomas.
Molecular carcinogenesis - 1 Jan 1993
Smith M L, Chandar N, Lombardi B
Abstract excerpt
Abnormalities of the retinoblastoma (Rb) gene have been reported in some human cancers, including hepatocellular carcinomas (HCCs). We examined by Southern blotting the status of the Rb gene in HCCs induced in rats in four experimental models. A low frequency of Rb gene alterations, detected as n...
Topics
- Alleles
- Animals
- Blotting, Southern
- DNA
- Gene Deletion
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Genes, Retinoblastoma
- Immunoblotting
- Liver Neoplasms, Experimental
- Male
- Mice
- Nucleic Acid Hybridization
- Precipitin Tests
- Rats
- Rats, Inbred F344
- Retinoblastoma Protein