Article
Low frequency of retinoblastoma gene alterations in rat hepatocellular carcinomas.
Molecular carcinogenesis - 1 Jan 1993
Smith M L, Chandar N, Lombardi B
Abstract excerpt
Abnormalities of the retinoblastoma (Rb) gene have been reported in some human cancers, including hepatocellular carcinomas (HCCs). We examined by Southern blotting the status of the Rb gene in HCCs induced in rats in four experimental models. A low frequency of Rb gene alterations, detected as novel hybridizing bands unique to each tumor, was observed. Expression of the Rb protein product was examined in the...
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