Article
Reduced expression of glutathione S-transferase Yb2 during progression of chemically induced hepatocellular carcinomas in Fischer 344 rats.
Hepatology (Baltimore, Md.) - 1 Jul 1994
Stalker M J, Kocal T E, Quinn B A, Gordon S G, Hayes M A
Abstract excerpt
We followed the expression of several glutathione S-transferase subunits in altered foci, liver neoplasms and metastases produced in male Fischer 344 rats by a modified Solt-Farber protocol, to determine whether components of the resistant phenotype are lost during neoplastic progression. At 6 mo after initiation, altered foci and persistent nodules displayed increased immunohistochemical expression of...
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