Article
Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990
Horowitz J M, Park S H, Bogenmann E, Cheng J C, Yandell D W, Kaye F J, Minna J D, Dryja T P, Weinberg R A
Abstract excerpt
We have used polyclonal anti-synthetic peptide serum to study the role of retinoblastoma gene (RB) inactivation in a variety of human tumor cell lines. Our analysis indicates that inactivation of the RB protein, p105-Rb, is universal in retinoblastoma cells, vindicating the predictions of the Knu...
Topics
- Base Sequence
- Blotting, Southern
- DNA, Neoplasm
- DNA-Binding Proteins
- Eye Neoplasms
- Gene Expression Regulation, Neoplastic
- Humans
- Methionine
- Molecular Sequence Data
- Mutation
- Oncogenes
- Phosphoproteins
- Polymerase Chain Reaction
- Protein Biosynthesis