Article
Infrequent alterations of the p16INK4A gene in liver cancer.
International journal of cancer - 17 Jul 1996
Kita R, Nishida N, Fukuda Y, Azechi H, Matsuoka Y, Komeda T, Sando T, Nakao K, Ishizaki K
Abstract excerpt
We examined the genomic status of the p16INK4A (inhibitor of cyclin-dependent kinase 4 A) and cyclin-dependent kinase 4 (CDK4) genes in 62 human hepatocellular carcinomas (HCCs), 5 cholangiocellular carcinomas and 6 cell lines derived from human liver cancers. Although no samples showed the homoz...
Topics
- Base Sequence
- Carcinoma, Hepatocellular
- Carrier Proteins
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases
- Exons
- Gene Deletion
- Homozygote
- Humans
- Liver Neoplasms
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Proto-Oncogene Proteins
- Tumor Cells, Cultured