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Article

Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens.

Nature - 1 Jan 2000

Bouck N, di Mayorca G

Abstract excerpt

The chemical induction of malignant transformation in BHK cells seems to result from a somatic mutation. Stable transformants, whose frequency is significantly increased by mutagenic carcinogens, can revert to normal and often display temperature-restricted phenotypes indicative of an altered gene product.

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Source

Identifiers

PMID: 827710
DOI: 10.1038/264722a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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