Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens.

doi:10.1038/264722a0

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Article

Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens.

Nature - 1 Jan 2000

Bouck N, di Mayorca G

Abstract excerpt

The chemical induction of malignant transformation in BHK cells seems to result from a somatic mutation. Stable transformants, whose frequency is significantly increased by mutagenic carcinogens, can revert to normal and often display temperature-restricted phenotypes indicative of an altered gen...

Topics

4-Nitroquinoline-1-oxide
Animals
Carcinogens
Cell Line
Cell Survival
Cell Transformation, Neoplastic
Cricetinae
Methylnitrosourea
Mutation
Temperature

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