Article
Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia.
Surgery - 1 Jan 1997
Rivera J A, Rall C J, Graeme-Cook F, Fernández-del Castillo C, Shu P, Lakey N, Tepper R, Rattner D W, Warshaw A L, Rustgi A K
Abstract excerpt
BACKGROUND: K-ras oncogene mutations have been identified in up to 95% of pancreatic cancers, implying their critical role in their molecular pathogenesis. However, the earliest stage in which K-ras mutations can be detected in potential precursor lesions of pancreatic cancer remains unclear. This study evaluates pancreatic ductal hyperplasia in the setting of chronic pancreatitis, which predisposes to pancreatic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.