Article
Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia.
Surgery - 1 Jan 1997
Rivera J A, Rall C J, Graeme-Cook F, Fernández-del Castillo C, Shu P, Lakey N, Tepper R, Rattner D W, Warshaw A L, Rustgi A K
Abstract excerpt
BACKGROUND: K-ras oncogene mutations have been identified in up to 95% of pancreatic cancers, implying their critical role in their molecular pathogenesis. However, the earliest stage in which K-ras mutations can be detected in potential precursor lesions of pancreatic cancer remains unclear. Thi...
Topics
- Adult
- Aged
- Base Sequence
- Chronic Disease
- DNA
- Female
- Genes, ras
- Humans
- Hyperplasia
- Male
- Middle Aged
- Mutation
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Pancreatic Ducts
- Pancreatitis
- Polymerase Chain Reaction