Article
Oligomerization is not essential for growth suppression by p53 in p53-deficient osteosarcoma Saos-2 cells.
Biochemical and biophysical research communications - 6 Mar 1997
Ishioka C, Shimodaira H, Englert C, Shimada A, Osada M, Jia L Q, Suzuki T, Gamo M, Kanamaru R
Abstract excerpt
The carboxy-terminal portion of the p53 protein contains the tetramerization domain, and the introduction of multiple missense mutations in this domain disrupts the formation of p53 tetramers, resulting in the production of dimeric or monomeric forms of p53. It has recently been shown that a single missense or nonsense mutation in this domain affects the functional properties of p53 both in yeast and in mammalian...
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