Estrogen receptor mutations in tamoxifen-resistant breast cancer.

Article

Estrogen receptor mutations in tamoxifen-resistant breast cancer.

Cancer research - 15 Jan 1994

Karnik P S, Kulkarni S, Liu X P, Budd G T, Bukowski R M

Abstract excerpt

Clinical resistance to antiestrogens like tamoxifen is a major problem in the treatment of hormone-dependent breast cancers. Since the estrogen receptor plays a central role in mediating the effects of estrogens and antiestrogens, we hypothesized that mutations in the estrogen receptor could be o...

Topics

Amino Acid Sequence
Base Sequence
Breast Neoplasms
DNA, Complementary
DNA, Neoplasm
Drug Resistance
Female
Humans
Molecular Sequence Data
Mutation
Neoplasms, Hormone-Dependent
Phenotype
Receptors, Estrogen
Tamoxifen
Transcription, Genetic

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