Article
An analysis of tamoxifen-stimulated human carcinomas for mutations in the AF-2 region of the estrogen receptor.
The Journal of steroid biochemistry and molecular biology - 1 Aug 1996
Bilimoria M M, Assikis V J, Muenzner H D, Wolf D M, Satyaswaroop P G, Jordan V C
Abstract excerpt
The estrogen receptor (ER) contains two transcriptional activation domains: AF-1 and AF-2. AF-2 is dependent on a highly species-conserved region of the ER. It has been shown that site-directed point mutations of conserved hydrophobic amino acids within this region reduce estrogen-dependent trans...
Topics
- Carcinoma
- Endometrial Neoplasms
- Estrogen Antagonists
- Female
- Humans
- Mutation
- Neoplasms, Experimental
- Ovarian Neoplasms
- Receptors, Estrogen
- Sequence Analysis, DNA
- Tamoxifen